277. Variability in Infectivity of Primary Cell Cultures of Human Brain Tumors with HSV-1 Amplicon Vectors

Background and Purpose. The discrepancy between successful experimental gene therapy protocols and limited clinical translation might – among other reasons – be due to the variability in infectivity and transgene expression in tumors from different patients using vectors. We investigated the variability in infectivity of cells derived from primary brain tumor samples from different patients using HSV-1 amplicons.