von Willebrand Factor/Factor VIII Concentrate (Humate-P®) Is Safe and Effective in the Prevention of Perioperative Bleeding in Patients with Very Low von Willebrand Factor: Ristocetin Cofactor (VWF:RCo).

Optimal dosing to prevent excessive surgical bleeding in von Willebrand Disease (VWD) was investigated in an open-label study of replacement therapy with a von Willebrand factor/factor VIII concentrate (VWF/FVIII, Humate-P ® ). This analysis focused on the subset of patients with very low VWF, defined as those with baseline VWF:RCo levels of