Potent and selective, sulfamide-based human beta 3-adrenergic receptor agonists.

A series of sulfamide-based analogs related to L-796568 were prepared and evaluated for their biological activity at the human β 3 -adrenergic receptor (AR). This modification allows for a significant reduction in molecular weight, while maintaining single-digit nanomolar potencies at the β 3 -AR and high selectivities versus the β 1 - or β 2 -AR.