Is Guanidine a Marker of Peroxidation in Uremics

There are many reports concerning the toxicity of oxygen in various disease states1–4 Recently, attention has been called to the unfavorable effects of active oxygen in renal diseases5–9. We have reported that the hydroxyl radical plays an important role in vitro10 and in isolated rat hepatocytes11 in the peroxidation of creatinine (CRN) to methylguanidine (MG), a guanidino compound known to be a potent uremic toxin. In this study, we investigate the correlation between some markers of the peroxidative state and the concentration of various guanidino compounds in the sera of patients undergoing regular hemodialysis.