A kind of preparation method of Pentafluorophenol

The present invention relates to organic synthesis field, more particularly to a kind of preparation method of Pentafluorophenol.The present invention provides a kind of preparation method of Pentafluorophenol, comprises the following steps：（1）Hoffmann rearrangement reaction：Formula II compound is subjected to rearrangement reaction under conditions of alkali, halogenating agent are present, formula III compound is prepared；（2）Diazonium hydrolysis：Formula III compound and nitroso compound are subjected to diazo-reaction, reaction is hydrolyzed under conditions of catalyst presence, compound of formula I is prepared.The preparation method raw material of Pentafluorophenol provided by the present invention is easy to get, whole reaction synthetic route is short, reaction condition is gentle and product purification is easy to operate, product purity is high, steady quality, reaction scheme is with low cost on the whole, is adapted to industrialization large-scale promotion and uses.