Modulation of in vitro immunoglobulin production by prostaglandins

This study showed the affection of prostaglandins (PG) on the in vitro IgG, IgM production by pokeweed mitogen stimulated normal human peripheral blood lymphocytes. Concentrations of PGE1 and PGA1 in excess of 10-6 M were suppressive. PGE2 and PGs of the F series were less suppressive and significant suppression was seen in concentrations greater than 10-5 M. Indomethacin added to cell cultures did not enhance Ig production. This discrepancy between physiologic concentrations and the very large pharmacologic concentration necessary to suppress Ig synthesis in vitro makes the physiologic role of PG in the modulation of Ig synthesis questionable.