New horizons in predictive toxicology : current status and application

Introduction and overview computational modeling approaches: in silico tools for toxicity prediction, development of an evaluation support system for estimating repeated dose toxicity of chemicals based on chemical structure, towards a common regulatory framework for computational toxicology: current status and future perspectives, information, informatics and modeling in predictive toxicology in vitro approaches in predicting toxicity: cellular stress and in vitro predictive toxicology, in vitro genotoxicity, cardiac toxicity prediction: to simplify, or to integrate, that is the question, in vitro approaches for determining liver specific toxicity of new drug candidates, human-based in vitro experimental systems for the assessment of human-specific adverse drug effects: scientific concepts, current applications and promising approaches, models of organ injury,mitochondrial toxicity in vivo approaches in predicting toxicity: nonclinical models for the evaluation of mechanisms of toxicity,in vivo genetic toxicology: application to cancer risk assessment, predicting hepatic toxicity in vivo, immunotoxicity testing,reproductive toxicity,toxicity biomarkers,renal toxicity, integrative approaches to toxicity prediction, metabolism-based toxicity prediction,impact of drug transporters in the pharmacological and adverse reactions of drugs,toxicokinetics, the role of computational systems biology models in toxicity testing in the 21st century: an example with predictive multi-scale models of the liver, animal models of idiosyncratic, drug-induced liver injury