Полиморфизм гена N-ацетилтрансферазы (NAT-2) у пациентов с туберкулезом органов дыхания

Polymorphism of a gene of N-acetyltransferase (NAT-2) at 100 patients with tuberculosis of the respiratory organs receiving treatment in a hospital No. 1 of GBUZ JSC Oblastnoy klinichesky protivotuberkulezny dispanser of Astrakhan in 2015 was studied. Men 61 (61%), women 39 (39%). The age of patients made from 18 to 60 years. It is established that heterozygotes with mainly slow metabolism S2/S3 prevailed; S1/S2; S3/n; S2/n; S1/S3 56%. The clinical symptomatology of tuberculosis of respiratory organs of patients of slow metabolites which was more expressed than at average and fast acetylators (r = 0,97). The X-ray pattern was characterized extended (more than three segments) by a lesion of a pulmonary tissue in the form of infiltration more often in group of slow acetylators (64,3%; r = 0,91; р = 0,017). The lesion of a pulmonary tissue in the form of disintegration in larger number of cases was defined also in group of slow metabolites (73,2%; r = 0,94; р = 0,05). Whereas the abatsilirovaniye of patients and a resorption of infiltrative changes, closing of cavities of disintegration of a pulmonary tissue is reached in later terms (in 6 and 7 months of therapy) in group of fast acetylators.