DNA Microviscosity Converts Ruthenium Polypyridyl Complexes to Effective Photosensitizers
2020
A unique radiative decay engineering strategy using DNA microviscosity for the
generation of ruthenium polypyridyl complex (RPCs) mediated singlet oxygen for selective
damage of DNA and killing cancer cells is reported. This investigation also demonstarte the
effect of light-driven RPCs on bacterial growth arrest, through DNA nick, and differential
localization in cancer and non-cancer cells. Moreover, upon binding with DNA, RPCs
experience high local microviscosity, which causes significant enhancement of the excited
state lifetime and thus generates singlet oxygen. The visible-light-triggered singlet-oxygen
efficiently produce nick in DNA and inhibits bacterial growth. RPCs also localize inside the
nucleus of the cancer cell and in the vicinity of the nuclear membrane of non-cancerous cells,
confirmed by live-cell confocal microscopy. The results provide a facile platform for the novel
antibiotic intended discovery combined with cancer therapy.
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