Suzuki Coupling Reactions of (E)- and (Z)-Chloroenynes with Boronic Acids: Versatile Access to Functionalized 1,3-Enynes

A stereoselective, palladium-catalyzed, cross-coupling reaction between chloroenynes 4 and boronic acids was successfully developed. This procedure is general and provides desired functionalized enynes 1 in high yields. The scope and limitations of this new reaction are described.