RGS proteins: more than just GAPs for heterotrimeric G proteins

Abstract Members of the newly described RGS family of proteins have a common RGS domain that contains GTPase-activating activity for many Gα subunits of heterotrimeric G proteins. Their ability to dampen signalling via Gα i -, Gα q - and Gα 12/13 -coupled pathways makes them crucial players in mediating the multitude of cellular processes controlled by heterotrimeric G proteins. Some RGS proteins also contain additional motifs that link them to other signalling networks, where they constitute effector-type molecules. This review summarizes recent findings on RGS proteins, especially those that implicate RGS proteins in more than just enhancing the GTPase activity of their Gα subunit targets.