Short Communication Effect of Zinc on ( 3 H)Thymidine, ( 3 H)Uridine and ( 3 H)Glicine Incorporation in the Tissues of Rats Prenatally Exposured to Cadmium

H]glicine (incorporated to protein) 1 μCi/kg IP. Four hours later rats were sacrificed by decapitation and parts of the brain and peripheral tissues were excised and examined for radioactivity in a liquid scintillation counter. Results were presented as a desintegration per minute – DPM/100 mg wet tissue weight, which expressed labeled substances incorporation. Prenatal cadmium exposure decreased incorporation of thymidine, uridine, and glicine in all examined tissues and organs. A single injection of zinc, preceding cadmium consumption, attenuated the effects of cadmium on incorporation of examined substances in peripheral organs, mostly liver, kidney, and pancreas. We concluded and confirmed our previous founding that a single zinc inection prior to cadmium exposure prevents some of its toxic effects on DNA, RNA, and protein synthesis in peripheral tissues of mammals.