Robust Synthesis of C-terminal Cysteine-Containing Peptide Acids through A Peptide Hydrazide-Based Strategy
2019
A new robust strategy was reported for the epimerization-free synthesis of C-terminal Cys-containing peptide acids through mercaptoethanol-mediated hydrolysis of peptide thioesters prepared in situ from peptide hydrazides. This simple-to-operate and highly efficient method avoids the use of derivatization reagents for resin modification, thus providing a practical avenue for the preparation of C-terminal Cys-containing peptide acids.
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
34
References
5
Citations
NaN
KQI