SYNTHESIS OF PROCOAGULANT ANTIHÆMOPHILIC FACTOR IN VITRO
1978
Abstract The cells which produce the procoagulant part of antihaemophilic factor (factor VIII-C) in normal people have remained unknown. Normal blood leucocytes cultured in vitro with phytohaemagglutinin synthesised a procoagulant with the properties of factor VIII-C. The procoagulant was inhibited by human VIII-C inhibitor and itself absorbed human VIII-C inhibitor-properties which are regarded as specific for factor VIII-C. Unexpectedly, cultured leucocytes from haemophiliacs also synthesised the procoagulant in similar amounts. Possible explanations and implications of these findings are briefly considered.
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