RNF11, a new piece in the A20 puzzle

The ubiquitin‐editing protein A20 limits the duration of NF‐κB activation and is essential to control inflammatory responses. Recent experiments have established that A20 mediates its inhibitory function in a complex with two other proteins, TAX1BP1 and the E3 ligase Itch. In a paper published in this issue, it is shown that RNF11 is also a critical component of the A20 ubiquitin‐editing complex.