Clinical value of plasma 1,3-β-D-glucan on diagnosis of deep fungal infection in patients with non-agranulocytosis.

OBJECTIVE To study the clinical value of(1-3)-β-D-glucan in diagnosis of invasive fungal infection in patients with non-agranulocytosis.METHODS Microbiology Kinetic Rapid Reader MB-80 was used to detect plasma levels of(1-3)-β-D-glucan.RESULTS The mean level of plasma(1-3)-β-D-glucan in healthy people control group was(0.003±0.002) ng/L,in deep fungal infection group was(0.188±0.207)ng/L and in bacterial infection group was(0.008±0.006)ng/L.The plasma(1-3)-β-D-glucan concentration in control group and deep fungal infection group showed statistical difference(P0.01).But in healthy group compared with that of bacterial infection group there,was no statisticol difference(P0.05).CONCLUSIONS Plasma(1-3)-β-D-glucan can provide reliable information for deep fungal infection in early stage when 0.02ng/L are considered as cut-off,the plasma(1-3)-β-D-glucan provides an ideal sensitivity and specificity.