Abstract 12001: Atrial Fibrillation Induces Ventricular Dysfunction via Altered Ca2+ Handling and Oxidative CaMKII Activation in the Human Heart

Steffen Pabel,M. Knierim,Thea Stehle,Felix Alebrand,Michael Paulus,Marcel Sieme,Melissa Herwig,Thomas Koertl,Brisca Wenner,Senka Ljubojevic-Holzer,Nataliya Dybkova,Simon Sedej,Daniel Scherr,Christoph Brochhausen,Gerd Hasenfuss,Lars S. Maier,Nazha Hamdani,Katrin Streckfuss-Bömeke,Samuel Sossalla

Abstract 12001: Atrial Fibrillation Induces Ventricular Dysfunction via Altered Ca2+ Handling and Oxidative CaMKII Activation in the Human Heart

2021

Steffen Pabel
M. Knierim
Thea Stehle
Felix Alebrand
Michael Paulus
Marcel Sieme
Melissa Herwig
Thomas Koertl
Brisca Wenner
Senka Ljubojevic-Holzer
Nataliya Dybkova
Simon Sedej
Daniel Scherr
Christoph Brochhausen
Gerd Hasenfuss
Lars S. Maier
Nazha Hamdani
Katrin Streckfuss-Bömeke
Samuel Sossalla

Introduction: The effects of atrial fibrillation (AF) on left ventricular (LV) function are poorly understood. Clinical data indicate that the arrhythmic component of AF may contribute to LV dysfun...

Keywords:

Cardiology
Atrial fibrillation
Ca2+/calmodulin-dependent protein kinase
human heart
Internal medicine
Heart failure
calcium handling
Oxidative phosphorylation
Medicine

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