Antibodies to islet tissue of the pancreasin patients with hormone-dependent tumors

Islet b-cell antibodies (ICA) were studied by immune fluorescence test in the blood serum of total of 192 individuals. Blood was sampled after previously nocturnal starving in 22 cancer patients with evident type 2 diabetes mellitus (DM2) (in those mainly with cancer of the breast (BC) and corpus uteri (CUC)), in 124 patients without diabetes (55 patients with BC and 69 patients with CUC), and in 41 healthy individuals. The study revealed ICA in 13.6% of the patients with hormone-dependent tumors and DM2, in 8.3% of the patients with BC and CUC and impaired glucose tolerance, in 6.6% of the patients with normal tolerance, ICA were absent in the healthy individuals (a comparison group). The detection of ICA in patients without signs of DM2 was associated with weight gain, the trend towards hypertriglyceridemia and transient hyperinsulinemia, with the elevated blood concentrations of thy­roglobulin and its antibodies. It is concluded that autoimmune disturbances of this kind are peculiar not only to patients with MD1 and, in their combination in persons aged above 40-50 years with a complex of hormone-dependent metabolic disturbances appeared as insulin-resistance syndrome should be regarded as an object for preventive measures in diabetology and oncoendocrinology.