Use of iPSC-derived brain organoids to study human brain evolution

Abstract Recent advances in stem cell, genome editing, and iPSC technologies have made it possible to study human brain evolution using this iPSC-derived brain organoids as a model system. In this chapter, we will explore the evolution of the human brain and the central nervous system and discuss what we can learn from genomic comparisons studies. We will also examine the model organisms used to study gene expression and cell biology and delve into the new world of iPSC-derived brain organoids and what this new model system can tell us about human brain evolution.