Significance of laboratory tests for differential diagnosis of acute renal allograft rejection and acute cyclosporine nephrotoxicity

: The most frequent causes of renal allograft function deterioration in early postransplantation period are aucte rejection (AR) and acute cyclosporine nephotoxicity (CyA NT). In order to contribute to noninvasive diagnostics in differential diagnosis of these two disorders, glomerular and tubular function in 40 patients during 2-3 weeks after renal transplantation, were followed-up. The results showed that ischaemia, during any act of transplantation provoked functional and structural disorders of renal allografts. During acute rejection serum creatinine level was increased diuresis, sodium and beta-2 microglobulin levels were decreased, whyle there was no significant change in the urinary enzymes ativity. In acute CyA NT there was significantly greater fractional excretion of sodium and beta-2 mikroblobulin, as well as activity of N-acetly-beta-d glukosaminidase and alkaline phosphatase in urine in comparison to other examined groups.