Expressiom of calcium ATPase in different tissues of protein deficient rats supplemented with Moringa olifera leaves (809.6)

Ca2+-ATPases are key proteins for the maintenance of calcium homeostasis and essential to the correct functioning of cell machinery. Reports indicates that exposure of cell to oxidative injury will affect Ca2+-ATPase. In this study, we investigated the effect of Protein energy malnutrition (PEM) on Ca2+-ATPases and the ameliorating effect of Moringa oliefera leaves. Eighteen Wistar rats randomized into groups A and B were used for the study. Group A (12 rats) were placed on protein deficient diet while group B (6 rats) were placed on protein sufficient diet. They were maintained on respective diets for 6 weeks after which all rats in group B and 6 rats in group A were sacrificed. The remaining rats in group A (relabeled as C) were maintained on protein deficient diet supplemented with Moringa oliefera leaves for another 6 weeks and then sacrificed. The skeletal muscle, brain and liver were removed and homogenized. Ca2+-ATPase specific activities in the selected tissues and the enzyme’s kinetic constants w...