Synthesis of 2/6‐(polychloromethyl)pyridine‐carboxylates

Due to their relationship to certain bio-active 2,6-(polyfluoromethyl)-3,5-pyridinedicarboxylates 12, methodology was developed to prepare new, but analogous 2/6 (polychloromethyl)pyridinecarboxylates 6, 9, 10, 13, 18 and 20. Successful methods to prepare these materials include several chlorination procedures, mixed Hantzsch sequences, and aluminum chloride interchanges with 12 and 16.