Synthesis of novel ellipticine analogues and their inhibition of Moloney leukaemia reverse transcriptase
1996
Abstract Two new ellipticine analogues were synthetized as potential non nucleoside inhibitors of reverse transcriptase and were tested on Moloney leukaemia virus reverse transcriptase in vitro . Both derivatives ( 9a,b ) showed considerable inhibitory effect; ID 50 was found to be in the range of 2.8 to 4.5 × 10 −5 M.
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