[Comparative evaluation of the effect of vitamin E deficiency on lipid peroxidation and Ca2+ transport in heart and skeletal muscles].

: 10-fold decrease of alpha-tocopherol content in blood serum, distinct increase in hemolysis of erythrocytes and activation of lactate dehydrogenase in blood plasma were found in rats kept on a vitamin E deficient diet within 2 months as compared with control. Content of alpha-tocopherol was decreased in myocardium 3.4-fold and in skeletal muscles--5.4-fold. Lipid peroxidation was activated in myocardium and skeletal muscles under conditions of vitamin E deficiency. Content of diene conjugates and Schiff bases was increased by 30-60% in these tissues; content of malonic dialdehyde--the secondary product of lipid peroxidation--was increased in myocardium by 60% and in skeletal muscles--4-fold. Activity of lysosomal enzymes was altered only slightly in myocardium, whereas in skeletal muscles unsedimented activity of acid phosphatase was distinctly increased. The activation of impairing factors observed led to deterioration of Ca2+ transport functions of membranes in myocardium by 30% and in skeletal muscles--4-fold. The data obtained suggest that heart muscle is better protected against vitamin E deficiency as compared with skeletal muscle. Physiological importance of these results is discussed.