Radiation-Induced Osteosarcoma of the Temporal Bone

A 32-year-old female suffered from a bulging mass over the right temporal area 4 years after radiotherapy for intraventricular neurocytoma. Computed tomography and magnetic resonance imaging revealed an osteolytic lesion over the right temporal bone. The patient underwent a craniotomy procedure for resection of the tumor, and the histological diagnosis was osteosarcoma. Postoperative adjuvant chemotherapy was administered. However, local recurrence developed 8 months later, and the patient again underwent surgical resection and chemotherapy. Though aggressively treated, the patient deteriorated due to local recurrence and lung metastasis, and she died 14 months after the diagnosis. Ultimately, radiation-induced osteosarcoma of the skull bone is a rare complication of radiotherapy for brain tumor, with a generally poor prognosis.