Differential expression of the c-jun proto oncogene during the cellular response to ionizing radiation is deminished by protein kinase C inhibitors

of DNA dsb were, therefore, studied in the above cell lines using a pulse field gel electrophoresis technique, the asymetric field inversion gel electrophoresis (AFIGE). Small variations were observed in the induction and repair of DNA dsb in these two cell lines that could be largely explained by differences in the distribution of cells in the various phases of the cell cycle. These results suggest that the radioresistance of 3.7 cells may not be mediated by alterations in their capacity to repair DNA dsb. It is hypothesized that alterations in repair and expression of potentially lethal damage underlies this phenomenon.