FT-IR Spectroscopic Assay Method for Amlodipine Besylate in Bulk and Tablet Formulations

A simple, precise and rapid method has been developed for the quantification of Amlodipine Besylate (AMB) using FT-IR technique in bulk and tablet formulations. The method involves the measurement of absorbance of carbonyl group (C=O) peak at 1676 cm -1 . The limit of LOD and limit of LOQ were 0.001mg and 0.032mg. The proposed method was validated for pharmaceuticals in tablet form and %RSD was found to be less than 2 with recovery levels >98%.