327 Combination of MDM2 antagonists with RAS pathway inhibitors in colorectal cancer

M. Martin, E. Anscombe, E. Meschini, D. Staunton, M. Geitmann, U.H. Danielson, L.Z. Wang, R. Mora Vidal, T. Reuillon, B.T. Golding, D.R. Newell, S. Wedge, M.E.M. Noble, J.A. Endicott, R.J. Griffin. Newcastle University, Northern Institute for Cancer Research, Newcastle-upon-Tyne, United Kingdom; University of Oxford, Department of Biochemistry, Oxford, United Kingdom; Newcastle University, NICR and Department of Chemistry, Newcastle upon Tyne, United Kingdom; Beactica AB, Uppsala, Sweden; Uppsala University, Department of Chemistry, Uppsala, Sweden; Newcastle University, Newcastle Cancer Centre NICR, Newcastle upon Tyne, United Kingdom