Assessment of ischaemia modified albumin in unstable angina and its correlation with selected acute phase reactants

Abstract: Objective: There is evidence that ischaemia modified albumin increases (IMA) in acute coronary syndrome but enough work has not been done in assessing the correlation between IMA and inflammatory markers in unstable angina. The aim of study was to observe whether ischaemia modified albumin would significantly be altered in unstable angina patients and also whether the same would be correlated with selected acute phase reactants. Method: The present hospital based, non interventional, cross sectional study was undertaken in Medical College and Hospital, Kolkata. Forty seven cases of unstable angina (UA) and fifty suitable controls were enrolled for the study. Serum ischaemia modified albumin (IMA), serum albumin, serum total cholesterol, serum high-sensitivity C-reactive protein (hsCRP), serum ceruloplasmin and serum transferrin were measured in blood from the study population. Results: Serum ischaemia modified albumin and hsCRP (P < 0.001) were significantly higher in UA cases whereas serum transferrin (P < 0.001) and albumin (P < 0.001) were significantly lower in cases as compared to controls. IMA was not correlated with acute phase reactants. Serum IMA (P-0.06) was not considered as an important inflammatory marker in UA. However, serum hsCRP and serum transferrin play significant role (P