Pyrazole-type N-p-methylphenyl maleimide derivative with chromone structure, and preparation method and application thereof

The invention discloses 3-(6-bromine-4-oxygen-4H-chromone)-1-phenyl-5-p-methylphenyl-1, 6a-dihydrogen pyrroline [3, 4-c] pyrazole-4, 6 (3aH, 5H)-diketone, and a preparation method and application thereof. According to the preparation method, a chromone structure is imported on the basis that a pentabasic pyrazole ring is introduced into N-p-methylphenyl maleimide according to a 1, 3-dipole cycloaddition method, and the novel 3-(6-bromine-4-oxygen-4H-chromone)-1-phenyl-5-p-methylphenyl-1, 6a-dihydrogen pyrroline [3, 4-c] pyrazole-4, 6 (3aH, 5H)-diketone is compounded. The compound has good inhibition effect on tumor cell strains, has higher inhibition ratio and selectivity for leukemia cells, and has good industrial application prospect in preparation of antineoplastic drugs and the like.