DEPROTECTION OF 3,4-DIMETHOXYBENZYL (3,4DMB) GROUP ON γ-LACTAM NITROGEN USING PHENYLIODINE(III) BIS(TRIFLUOROACETATE) (PIFA) : APPLICATION TO ISOINDOLINONE COMPOUNDS (Dedicated to Dr. Albert Padwa on his 75th birthday)

Tadashi Katoh,Kazuhiro Watanabe,Hiroaki Shibata,Yu Imai

DEPROTECTION OF 3,4-DIMETHOXYBENZYL (3,4DMB) GROUP ON γ-LACTAM NITROGEN USING PHENYLIODINE(III) BIS(TRIFLUOROACETATE) (PIFA) : APPLICATION TO ISOINDOLINONE COMPOUNDS (Dedicated to Dr. Albert Padwa on his 75th birthday)

2012

Tadashi Katoh
Kazuhiro Watanabe
Hiroaki Shibata
Yu Imai

The dimethoxybenzyl group represents an optimal protective group for the secondary amide (γ-lactam) moiety of an isoindolinone ring with an extraordinarily high polarity and difficult handling characteristics.

Keywords:

Nitrogen
Moiety
Photochemistry
Phenyliodine(III) bis(trifluoroacetate)
Organic chemistry
Amide
Lactam
Chemistry

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