[297-POS]: Vascular reactivity and carotid artery intima media thickness (IMT) in women with early and late-onset preeclampsia and chronic hypertension

Objectives This study aimed to assess vascular endothelial reactivity and carotid intima-media thickness in women with early- and late-onset preeclampsia, and with chronic hypertension. Methods A total of 28 women with uncomplicated pregnancies, 25 women with early-onset preeclampsia, 36 women with late-onset preeclampsia and 26 women with chronic hypertension were evaluated. We measured flow-mediated vasodilation in the brachial artery (FMD; marker of endothelial function), and intima-media thickness in the carotid artery (IMT; marker of atherogenesis) in women with early-onset preeclampsia during pregnancy and three months after delivery, and compared these parameters with those in normal, late-onset preeclampsia, and chronic hypertension. Results FMD was significantly lower during pregnancy in both preeclamptic and chronic hypertension groups, compared to the control group. FMD in late-onset preeclamptic group significantly increased and normalized 3 months after delivery. Although, FMD in the early-onset preeclamptic and chronic hypertension groups significantly increased 3 months after delivery, it showed still lower than control. IMT in early-onset preeclamptic and chronic hypertension groups, but not late-onset preeclamptic group, were significantly larger than that in control group. Conclusions These findings suggest that endothelial dysfunction is irreversible and atherosclerotic changes might be enhanced in women with early-onset preeclampsia and chronic hypertension. Disclosures T. Mori: None. K. Watanabe: None. A. Iwasaki: None. C. Kimura: None. A. Wakatsuki: None.