Peptide H Reduces IL-6 Expression in Human Breast Cancer MDA-MB-231 Cells

Chungkookjang (fermented soybeans) contains diverse peptides. Human breast cancer MDA-MB-231 cells were treated with peptide H derived from Chungkookjang, and expression in the cells was conspicuously repressed, suggesting peptide H`s regulation of IL6 since IL6 is induced by . The structure of peptide H was different from those of glucocorticoid and dexamethasone, suggesting different mechanisms of expression suppression. Peptide H which reduces expression can be developed as drugs for cancer, rheumatoid arthritis and Crohn`s disease, after more investigation.