Anti-inflammatory Activity of Aronia Berry Polyphenols in Jurkat T Cells

INTRODUCTIONInflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract resulting from an aberrant immune response to the microbiota. T cells and their cytokines influence contribute to the ongoing inflammation in IBD. Diets rich in fruits and vegetables have been shown to decrease the risk of developing IBD. Dietary polyphenols are considered to be responsible for many of the benefits of fruit and vegetable consumption. Aronia berries are a concentrated source of polyphenols including anthocyanins, proanthocyanidins, and phenolic acids. Polyphenols, in general, have limited intestinal absorption and are extensively metabolized by the gut microbiota. Microbial catabolism may contribute to the health benefits associated with polyphenol consumption. OBJECTIVEThe objective of this study was to determine the anti-inflammatory activities of an aronia berry extract, aronia polyphenol fractions, and microbial polyphenol metabolites in Jurkat T cells. METHODSAronia anthocyanin...