TSPYL5 suppresses p53 levels and function by physical interaction with USP7

Mirjam T. Epping,Lars A.T. Meijer,Oscar Krijgsman,Johannes L. Bos,Pier Paolo Pandolfi,René Bernards

TSPYL5 suppresses p53 levels and function by physical interaction with USP7

2011

Mirjam T. Epping
Lars A.T. Meijer
Oscar Krijgsman
Johannes L. Bos
Pier Paolo Pandolfi
René Bernards

The genetic locus encompassing TSPYL5 is frequently amplified in breast cancer. TSPYL5 is now shown to repress p53 accumulation by interacting with and inhibiting the p53 de-ubiquitylating enzyme USP7.

Keywords:

Enzyme
Breast cancer
Locus (genetics)
Cancer research
Genetics
Biology
physical interaction

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