Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells

Robert W. Robey,Tomasz Obrzut,Suneet Shukla,Orsolya Polgar,Sira Macalou,Julian C. Bahr,Attilio Di Pietro,Suresh V. Ambudkar,Susan E. Bates

Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells

2009

Robert W. Robey
Tomasz Obrzut
Suneet Shukla
Orsolya Polgar
Sira Macalou
Julian C. Bahr
Attilio Di Pietro
Suresh V. Ambudkar
Susan E. Bates

Purpose ABCG2 overexpression has been linked to resistance to topoisomerase inhibitors, leading us to examine the potential interaction between ABCG2 and becatecarin.

Keywords:

Gene expression
Topoisomerase
Biochemistry
Becatecarin
ATP-binding cassette transporter
Cell biology
Abcg2
Cell
In vitro
Topoisomerase inhibitor
Internal medicine
Endocrinology
Biology

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