Synthesis of 2-(1 H -indol-3-yl)pyridine derivatives through multi-component reaction

A straightforward and practical approach is established for the synthesis of 2-(1H-indol-3-yl)pyridine derivatives achieved through the one-pot three-component reaction of chalcone, 3-(2-cyanoacetyl)-1H-indole and ammonium acetate. This method offers several advantages such as short reaction time, high yields, and simple procedure.