EFFECTS OF TRADITIONAL CHINESE MEDICINE TIANNIANYIN ON GLUTAMIC ACID CONTENT IN BRAIN OF AGED RATS

Objective:To observe the effects of traditional Chinese Medicine tiannianyin on glutamic acid (Glu) content in brain of aged rats.Methods:40 SD rats were divided into 4 groups at random:normal group, aging model group,tiannianyin group and negative control group,and each group had 10 rats.The sub-acutely aging model rats were made by injecting D-gal into abdominal cavity continually.High performance capillary electropheresis (HPCE) was used to detect the contents of Glu in cerebral cortex,hippocampus of rats in each group.Results:The Glu content in cerebral cortex,hippocampus of rats in aging model group increased signifi- cantly (compared with normal rats P0.01);Traditional Chinese medicine tiannianyin could decrease the Glu content in different brain region of aged rats obviously (tinianyin group compared with aging model group:P0.01).Conclusions:Traditional Chinese medicine tiannianyin could improve the metabolism of Glu in brain of aged rats,and has the effects of delaying brain ageing.