Metastasis and stress reactions in the surgical resection of tumors

: Complex investigations of brain mediator systems, catecholamine metabolism, II-oxycorticosteroid level in blood plasma, histochemical study of hormonogenesis in adrenal medulla and adrenal cortex in C57N1 mice with metastatic Lewis (3LL) carcinoma showed that metastatic stimulation initiated by the removal of a tumour caused an intensive prolonged stress reaction which differed from the reaction to a surgical trauma without removing a tumour. It is supposed that neuroendocrinal stress reactions could to a considerable extent determine this metastatic stimulation.