Mesylate crystal form a of nicotinamide derivatives, preparation method therefor, and application thereof
2015
Disclosed are a mesylate crystal form A of nicotinamide derivatives, a preparation method therefor, and an application thereof. According to an XRPD atlas, the mesylate crystal form A of nicotinamide derivatives has diffraction peaks when 2θ=5.34, 10.341, 14.438, 15.841, 17.32, 18.301, 18.68, 19.005, 19.577, 20.26, 21.161, 21.859, 22.379, 23.04, 23.5, 24.177, 24.959, 25.881, 26.641, 27.18, 28.3, 28.999, 29.501, 31.96, 32.258, 33.999, 36.798, 37.38 and 41.297, wherein the error range of the value of 2θ is ±0.2. The mesylate crystal form A of nicotinamide derivatives provided by the present invention has good high-temperature stability, high humidity stability and illumination stability, can be applied to drugs for treating advanced non-small cell lung cancer, gastric cancer, liver cancer or breast cancer, and has good bioavailability; meanwhile, the qualitative and quantitative information provided by the mesylate crystal form A of nicotinamide derivatives has important significance for further researching of the curative effects of such solid drugs.
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