DNA-mediated reversible capture and release of circulating tumor cells with a multivalent dual-specific aptamer coating network

DNA-triggered reversible isolation and recovery of circulating tumor cells (CTCs) is presented based on a multivalent dual-specific aptamer-tethered rolling circle amplification (MA-RCA) network. The multivalent binding sites endow the MA-RCA network with a strong binding ability towards CTCs, and the repeated cell capture/release processes are also actualized in a noninvasive manner.