Ligand Conjugated Multimeric siRNAs Enable Enhanced Uptake and Multiplexed Gene Silencing

Jonathan M. Brown,James E. Dahlman,Kristin K. Neuman,Carla Alexandra Hernandez Prata,Monika Krampert,Philipp Hadwiger,Hans-Peter Vornlocher

Ligand Conjugated Multimeric siRNAs Enable Enhanced Uptake and Multiplexed Gene Silencing

2019

Jonathan M. Brown
James E. Dahlman
Kristin K. Neuman
Carla Alexandra Hernandez Prata
Monika Krampert
Philipp Hadwiger
Hans-Peter Vornlocher

Small interfering RNAs (siRNAs) conjugated to N-acetylgalactosamine (GalNAc) ligands have been used to treat disease in patients. However, conjugates with other ligands deliver siRNA less efficient...

Keywords:

Gene knockdown
Gene silencing
Conjugated system
Oligonucleotide
Biology
Biochemistry
Ligand
Small interfering RNA
in patient

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