Alkoxy pyrimidine-spiced 3-pyrrolidinylspirooxindole derivative and preparation method and application thereof

The invention discloses an alkoxy pyrimidine-spiced 3-pyrrolidinylspirooxindole derivative. Various substituted alkoxy pyrimidine-spiced 3-olefinic bond oxoindole derivatives, sarcosine and paraformaldehyde are subjected to reflux in an organic solvent, and 1,3-dipole 3+2 cycloaddition reaction is carried out to obtain the alkoxy pyrimidine-spiced 3-pyrrolidinylspirooxindole derivative. Skeletons including potential biological activity pyrimidine skeletons and 3-pyrrolidinylspirooxindole skeletons are significant medical intermediate analogues and pharmaceutical molecule analogues and capable of providing compound sources for biological activity screening and have important application value in medicine screening and pharmaceutical industry. According to tumor growth inhibition activity screening aimed at the derivatives, the derivatives have certain tumor cell growth inhibition activity and are expected to be applied to antitumor drugs.