Notch signaling is necessary for adult, but not fetal, development of ROR[gamma]t+ innate lymphoid cells

The development of RORγt+ innate lymphoid cells (ILCs) remains poorly defined. Golub and colleagues define the stages of fetal and adult RORγt+ ILC maturation and show that adult RORγt+ ILCs mature outside the bone marrow, in a Notch2-dependent manner.