Ondansetron-Induced Dystonia, Hypoglycemia, and Seizures in a Child

ObjectiveTo document ondansetron-induced dystonia, hypoglycemia, and seizures in a child.Case Summary:A 4-year-old boy was admitted with dystonia following an intravenous dose of ondansetron 2 mg (0,13 mg/kg) that he had received for vomiting that day. In the emergency department, he developed generalized tonic-clonic seizures lasting for a few minutes. He was administered lorazepam 1.5 mg (0.1 mg/kg) to control the seizures. His blood glucose level was 10 mg/dL; the hypoglycemia responded promptly to intravenous dextrose 10% (7 mL/kg). Serum electrolytes, renal profile, capillary blood gas, and results of a computed tomography scan of the brain were normal. Subsequent blood glucose values were within normal range. On follow-up after 7 days, the child was healthy with no recurrences of the symptoms. A provisional diagnosis of ondansetron-induced acute dystonia with seizures and hypoglycemia was made.Discussion:Ondansetron is an antiemetic known for its safety profile. There have been a few case reports of...