Frequency and predictors of bleeding events after 2nd generation drug-eluting stent implantation differ depending on time after implantation

Abstract Background Antiplatelet therapy is required after drug-eluting stent (DES) implantation, but bleeding events occur unexpectedly. We aimed to assess whether bleeding event predictors after 2nd generation DES (2nd DES) implantation differed by time after implantation. Methods We studied 1912 consecutive patients who underwent successful 2nd DES implantation (70 ± 10 years, 72% male). Bleeding events were recorded as early (≤1 year) and late (>1 year). Major bleeding events were defined as a composite of type 5, 3, and 2 bleeding in the Bleeding Academic Research Consortium criteria. Predictors were assessed using a Cox proportional hazard model. Results Bleeding event rates were 3.3%, 5.1%, and 6.7% at 1, 2, and 3 years, respectively, with the highest 1-year rate in year 1 ( p p 80 years and severe renal dysfunction (adjusted RR: 2.27, 2.02, respectively; p p Conclusion Frequency and predictors of bleeding events after 2nd DES implantation differ by time after implantation. Treatment strategies corresponding to individual patients are required.