Synthesis and evaluation of quinoxalinones as HIV-1 reverse transcriptase inhibitors

Abstract A series of 3,3-disubstituted quinoxalinones was prepared and evaluated as HIV-1 reverse transcriptase inhibitors. The N -allyl ( 6b and 6f ), N -cyclopropylmethyl ( 6a , 6g , 6h , and 6k ) and N -carboalkoxy ( 6m – 6y ) substituted compounds displayed activity comparable or better than Efavirenz and GW420867X.