Tumour-Infiltrating Lymphocytes in Colorectal Adenocarcinoma

Several studies have indicated that lymphocytes found in tumour area, known as TILs (tumour-infiltrating lymphocytes), can provide prognostic information in colorectal cancer (CRC). The purpose of this study was to evaluate degree of stromal TILs  according to histological grading of CRC. This study used  a cross sectional design method by taking random samples of data and formalin-fixed paraffin-embedded of colorectal adenocarcinoma patients treated in Dr. Wahidin Sudirohusodo Hospital and Hasanuddin University Hospital in Makassar during the period of 2014-2016. The histological grading of each sample was reviewed and  TILs were assessed according to recommendation of the International TILs Working Group, 2014 on hematoxylin-eosin (H-E)-stained sections. Based on histological grading it was found that from 98 samples, 23 samples (23.5%) were well-differentiated, 66 samples (67.3%) were moderately differentiated, and 6 samples were (9.2%) poorly differentiated. While based on degree of TILs found that low- and moderate-score were 38 (38.8%) and 42 (42.9%) samples respectively, and high-score were 18 (18.4%) samples. Data were analysed using the Chi-square test and a p value of 0.865 ( p > 0.05) was obtained and therefore it was concluded that there was no significant difference of degree of TILs according to histological grading of colorectal adenocarcinoma in this study.