The analysis of sHLA-G antigen blood serum concentration levels during radical therapy for gynecological malignancies.

e22192 Background: HLA-G is a non-classic major histocompatibility antigen (MHC) class Ib. The suppressive properties of HLA-G play an important role in escape from immune surveillance, a phenomenon of fundamental importance for the development of various types of cancer. The expression of HLA-G is involved in the development of malignant melanoma, ovarian, cervical and other types of cancers. It can be released into the extracellular space in a soluble form (sHLA-G) that retains biological activity. Methods: 215 patients with gynecological malignancies were included in this study. The blood serum levels of soluble HLA-G were measured prior to radical treatment: surgery and chemotherapy in ovarian cancer patients, radiochemiotherapy in patients with cervical cancer, and surgery followed by radiotherapy for those suffering from endometrial cancer. Long-term outcomes were observed. The patients were divided into three groups according to overall survival time. In the first group, OS was less than 2 years. T...