Синтез и противомикробные свойства аммониевых солей, содержащих замещенную бутин-2-ильную группу

A series of new monoammonium salts have been synthesized via interaction of 1-dimethylamino-4-diethylaminobutyn-2, 1-dimethylamino-4-piperidinobutyn-2, 1-dimethylamino-4-morpholinobutyn-2 with corresponding alkyl esters of monobromo(chloro)acetic acids. The study of antimicrobial activity of the obtained compounds showed that salts containing hydrophobic alkoxycarbonylmethyl radical exhibited pronounced antibacterial activity against Gram positive and Gram negative microorganisms.